Development of aqueous ternary nanomatrix films: a novel ‘green’ strategy for the delivery of poorly soluble drugs

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dc.cclicenceN/Aen
dc.contributor.authorKola-Mustapha, A.en
dc.contributor.authorArmitage, Daviden
dc.contributor.authorAbioye, A. O.en
dc.date.acceptance2016-11-03en
dc.date.accessioned2017-02-08T10:04:16Z
dc.date.available2017-02-08T10:04:16Z
dc.date.issued2016-11-05
dc.description.abstractAqueous polymeric films have potentially great values in drug development, particularly in controlled drug release and taste masking strategies. However the progressive polymer-particle coalescence that occurs randomly during film formation, curing and storage may render the film less permeable leading to erratic and unpredictable drug release profile. The focus of this study was to investigate the impacts of the in situ formation of polymer-drug nanoconjugate, at the interfacial nano-domains of two oppositely charged polymers, on the mechanism of film formation and to prepare aqueous ternary polymer-drug-polymer nanomatrix films as a novel green strategy for the delivery of ibuprofen, a model poorly soluble drug. Composite and Layer-by-Layer films were prepared by aqueous casting technique using the concept of combined polymer-drug self-assembly and polyelectrolyte complexation. The plain and drug-loaded nanomatrix films were characterized using SEM, AFM, FTIR, DSC and TGA. Ibuprofen formed spherical core-shell microstructures (4.55 - 9.73 μm) in gellan film. However in the presence of cationic dextran (Ddex), nanoconjugates (61.49±5.97 - 447.52±37.51 nm) were formed within the core of the film matrix. The composite films exhibited reduced tensile strength and lower elastic modulus with optimal conjugation efficiency of 98.14±1.19%, which correlates with higher dissolution efficiency (99.76%) compared to 47.37% in layer-by-layer (LbL) films, dictated by Ddex concentration. Generally, the mechanism of drug release was by Fickian diffusion, however anomalous transport or polymer relaxation was also observed at higher concentration of Ddex. This study demonstrated the potential application of aqueous drug-loaded nanomatrix films as controlled drug delivery strategy for ibuprofen, a model poorly soluble drug.en
dc.exception.reasonFull text not deposited within 3 months of acceptanceen
dc.funderN/Aen
dc.identifier.citationKola-Mustapha, A., Armitage, D. and Abioye, A.O. (2016) Development of aqueous ternary nanomatrix films: a novel ‘green’ strategy for the delivery of poorly soluble drugs. International Journal of Pharmaceutics, 515 (1-2), pp. 616-631en
dc.identifier.doihttps://doi.org/10.1016/j.ijpharm.2016.11.017
dc.identifier.urihttp://hdl.handle.net/2086/13228
dc.language.isoenen
dc.peerreviewedYesen
dc.projectidN/Aen
dc.publisherElsevieren
dc.researchgroupPharmaceutical Technologiesen
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en
dc.subjectAqueous nanomatrix filmen
dc.subjectcontrolled polymeric self-assemblyen
dc.subjecttuneable polymeric nanodomainen
dc.subjectternary nanoconjugateen
dc.subjectgreen strategy for drug deliveryen
dc.subjectmechanism of drug releaseen
dc.titleDevelopment of aqueous ternary nanomatrix films: a novel ‘green’ strategy for the delivery of poorly soluble drugsen
dc.typeArticleen

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