Gels for constant and smart delivery of insulin

Date

2020-06-01

Advisors

Journal Title

Journal ISSN

ISSN

Volume Title

Publisher

British Journal of Diabetes

Type

Article

Peer reviewed

Yes

Abstract

The focus of this review is the role of gelatinous materials for oral, transdermal and peritoneal insulin platforms as alternatives to the ubiquitous subcutaneous depot approach. Hydrogels that form hydrated, cohesive materials and the topologically complex micellar types can add ligand interaction, bond vulnerability and rheological characteristics to develop reliable programmed release, including closed loop (automated basal and bolus) activity in non-oral routes. In addition, the potential protection of the protein and likely increased paracellular uptake mean that orally active insulin is feasible. While unlikely to be suitable for closed loop delivery, the driver for gut absorption is not only to increase the convenience and decrease dosage trauma, but to target the mesentery-portal vasculature rather than peripheral tissue, thus improving hepatic glycogen equilibrium and reducing the obesogenic effect and hypoglycaemic episodes.

Description

Keywords

Citation

Taylor, M.J., Chauhan, K.P. and Sahota, T.S. (2020) Gels for constant and smart delivery of insulin. British Journal of Diabetes, 20 (1), pp. 41-51

Rights

Research Institute

Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)