Best Practice in the chemical characterisation of extracts used in pharmacological and toxicological research—The ConPhyMP—Guidelines

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dc.cclicenceCC BYen
dc.contributor.authorHeinrich, Michael
dc.contributor.authorJalil, Banaz
dc.contributor.authorAbdel-Tawab, Mona
dc.contributor.authorEcheverria, Javier
dc.contributor.authorKulić, Žarko
dc.contributor.authorMcGaw, Lyndy J.
dc.contributor.authorPezzuto, John M.
dc.contributor.authorPotterat, Olivier
dc.contributor.authorWang, Jia-Bo
dc.contributor.authorAppendino, Giovanni
dc.contributor.authorArroo, R. R. J.
dc.contributor.authorAtanasov, Atanas G.
dc.contributor.authorBarron, Denis
dc.contributor.authorBauer, Rudolf
dc.contributor.authorCañigueral, Salvador
dc.contributor.authorEfferth, Thomas
dc.contributor.authorFürst, Robert
dc.contributor.authorIzzo, Angelo A.
dc.contributor.authorKelber, Olaf
dc.contributor.authorKemper, Kathi
dc.contributor.authorMonagas, Maria
dc.contributor.authorPendry, Barbara
dc.contributor.authorPereda-Miranda, Rogelio
dc.contributor.authorRollinger, Judith
dc.contributor.authorRusso, Alessandra
dc.contributor.authorVerpoorte, Robert
dc.contributor.authorVisioili, Francesco
dc.contributor.authorVollmer, Günter
dc.contributor.authorWohlmuth, Hans
dc.date.acceptance2022-09-13
dc.date.accessioned2022-12-06T14:50:31Z
dc.date.available2022-12-06T14:50:31Z
dc.date.issued2022-09-13
dc.descriptionThe Advisory group on Consensus statement on the Phytochemical Characterisation of Medicinal Plant extracts (ConPhyMP) is a consortium of experts on Pharmacognosy and Phytochemistry open access articleen
dc.description.abstractBackground: Research onmedicinal plants and extracts derived fromthem differs from studies performed with single compounds. Extracts obtained from plants, algae, fungi, lichens or animals pose some unique challenges: they are multicomponent mixtures of active, partially active and inactive substances, and the activity is often not exerted on a single target. Their composition varies depending on the method of preparation and the plant materials used. This complexity and variability impact the reproducibility and interpretation of pharmacological, toxicological and clinical research. Objectives: This project develops best practice guidelines to ensure reproducibility and accurate interpretations of studies using medicinal plant extracts. The focus is on herbal extracts used in pharmacological, toxicological, and clinical/intervention research. Specifically, the consensus-based statement focuses on defining requirements for: 1) Describing the plant material/herbal substances, herbal extracts and herbal medicinal products used in these studies, and 2) Conducting and reporting the phytochemical analysis of the plant extracts used in these studies in a reproducible and transparent way. The process and methods: We developed the guidelines through the following process: 1) The distinction between the three main types of extracts (extract types A, B, and C), initially conceptualised by the lead author (MH), led the development of the project as such; 2) A survey among researchers of medicinal plants to gather global perspectives, opportunities, and overarching challenges faced in characterising medicinal plant extracts under different laboratory infrastructures. The survey responses were central to developing the guidelines and were reviewed by the core group; 3) A core group of 9 experts met monthly to develop the guidelines through a Delphi process; and. 4) The final draft guidelines, endorsed by the core group, were also distributed for feedback and approval to an extended advisory group of 20 experts, including many journal editors. Outcome: The primary outcome is the “Consensus statement on the Phytochemical Characterisation of Medicinal Plant extracts“ (ConPhyMP) which defines the best practice for reporting the starting plant materials and the chemical methods recommended for defining the chemical compositions of the plant extracts used in such studies. The checklist is intended to be an orientation for authors in medicinal plant research as well as peer reviewers and editors assessing such research for publicationen
dc.funderNo external funderen
dc.funder.otherWillmar Schwabe GmbH & Co. KGen
dc.identifier.citationHeinrich M, Jalil B, Abdel-Tawab M, Echeverria J, Kulić Ž, McGaw LJ, Pezzuto JM, Potterat O, Wang J-B, et al. (2022) Best Practice in the chemical characterisation of extracts used in pharmacological and toxicological research—The ConPhyMP—Guidelines. Frontiers Pharmacology, 13:953205en
dc.identifier.doihttps://doi.org/10.3389/fphar.2022.953205
dc.identifier.issn1663-9812
dc.identifier.urihttps://hdl.handle.net/2086/22353
dc.language.isoenen
dc.peerreviewedYesen
dc.projectidInitiate and coordinate an international consensus process involving editors of the leading scientific journals dedicated to phytotherapy and other stakeholders with the aim to define best-practice phytochemical characterization of herbal preparations used in pharmacological and clinical researchen
dc.publisherFrontiersen
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en
dc.subjectBest practiceen
dc.subjectextract characterisationen
dc.subjectmedicinal planten
dc.subjectanalytical methodsen
dc.subjectphytochemical analysisen
dc.subjectHPTLCen
dc.subjectHPLCen
dc.titleBest Practice in the chemical characterisation of extracts used in pharmacological and toxicological research—The ConPhyMP—Guidelinesen
dc.typeArticleen

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