Flow cytometry and light scattering technique in evaluation of nutraceuticals

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dc.cclicenceN/Aen
dc.contributor.authorMINDUKSHEV, I.V.
dc.contributor.authorKUDRYAVTSEV, I.V.
dc.contributor.authorSEREBRIAKOVA, M.K.
dc.contributor.authorTRULIOFF, A.S.
dc.contributor.authorGAMBARYAN, S.P.
dc.contributor.authorSUDNITSYNA, J.S.
dc.contributor.authorAvdonin, P. V.
dc.contributor.authorJenkins, R. O.
dc.contributor.authorGoncharov, N. V.
dc.date.acceptance2021
dc.date.accessioned2022-01-28T10:26:21Z
dc.date.available2022-01-28T10:26:21Z
dc.date.issued2021
dc.description.abstractToxic and mechanistic properties of nutraceuticals are not as extensively studied as those of pharmaceuticals. Flow cytometry is among the most popular techniques to investigate the modes and mechanisms of cytotoxic action of chemical compounds, though flow cytometry methods are not suitable for online registration of fast changes of cell volumes. Such registration is especially important for some types of cells, such as human erythrocytes having no nuclei and mitochondria. In this chapter, we describe a new device (LaSca, Biomedsystems Ltd, Russia) for the registration of kinetic changes in cell volume, morphology and aggregation. In addition, flow cytometry methods of cell viability assessment are overviewed paying attention to mechanisms of cell death and survival, and some cellular studies of nutraceuticals employing light scattering and flow cytometry techniques are given in short.en
dc.funderNo external funderen
dc.identifier.citationMINDUKSHEV I.V., KUDRYAVTSEV I.V., SEREBRIAKOVA M.K., TRULIOFF A.S., GAMBARYAN S.P., SUDNITSYNA J.S., AVDONIN P.V., JENKINS R.O. and GONCHAROV N.V. (2021) Flow cytometry and light scattering technique in evaluation of nutraceuticals. In: Gupta RC, Lall R, Srivastava A (eds). Nutraceuticals: Efficacy, Safety and Toxicity, Second Edition. San Diego: Elsevier, pp.379-393en
dc.identifier.doihttps://doi.org/10.1016/B978-0-12-821038-3.00026-4
dc.identifier.isbn9780128210383
dc.identifier.isbn9780128212462
dc.identifier.urihttps://hdl.handle.net/2086/21637
dc.language.isoenen
dc.peerreviewedYesen
dc.publisherElsevieren
dc.researchinstituteInstitute for Allied Health Sciences Researchen
dc.subjectflow cytometryen
dc.subjectlight scatteringen
dc.subjecttumor cellsen
dc.subjectred blood cellsen
dc.subjectcytotoxicityen
dc.subjectapoptosisen
dc.subjectnecrosisen
dc.subjecteryptosisen
dc.titleFlow cytometry and light scattering technique in evaluation of nutraceuticalsen
dc.typeBook chapteren

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