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MON-P095: The Effect of Fish Oil-Supplemented Gemcitabine Treatment on Leukotriene B4 Levels in Pancreatic Cancer
(Elsevier, 2017-09-18)
Pancreatic cancer (PC) is an aggressive cancer and is the 5th leading cause of cancer death in Western Europe and unfavourable prognosis is attributed to advanced disease at diagnosis and lack of effective therapy. The ...
Exploring lesbian, gay and bisexual patients’ accounts of their experiences of cancer care in the UK
(Wiley, 2016-04-20)
Despite greater recognition of rights and responsibilities around the care of cancer patients who identify as
lesbian, gay or bisexual (LGB) within healthcare systems in the United Kingdom, recent quantitative
evidence ...
Towards LGBTQ-affirmative cancer care and support: Barriers and opportunities
(2018-08-24)
Background: Survey data suggest that LGBT people report lower levels of satisfaction with healthcare for cancer than heterosexuals. This presentation summarises findings from recent qualitative research to understand the ...
The synthesis of chalcones as anticancer prodrugs and their bioactivation in CYP1 expressing breast cancer cells
(Bentham Science Publishers, 2017-12-11)
Abstract: Background: Although the expression levels of many P450s differ between tumour and
corresponding normal tissue, CYP1B1 is one of the few CYP subfamilies which is significantly
and consistently overexpressed in ...
Nobiletin bioactivation in MDA-MB-468 breast cancer cells by cytochrome P450 CYP1 enzymes.
(Elsevier, 2018-01-31)
Nobiletin is a fully methoxylated flavone that has demonstrated anticancer activity via multiple modes of action. In the present study, the metabolism and further antiproliferative activity of nobiletin was evaluated in ...
The Epstein-Barr virus-encoded LMP1 oncoprotein modulates cell adhesion via regulation of activin A/TGFbeta and beta1 integrin signalling
(Nature Scientific Reports, 2016-01-19)
Approximately 20% of global cancer incidence is causally linked to an infectious agent. Epstein-Barr virus (EBV) accounts for around 1% of all virus-associated cancers and is associated with nasopharyngeal carcinoma (NPC). ...
Sustained activation of P2X7 induces MMP-2-evoked cleavage and functional purinoceptor inhibition.
(Oxford Academic., 2017-08-18)
P2X7 purinoceptor promotes survival or cytotoxicity depending on extracellular ATP (eATP) stimulus intensity controlling its ion channel or P2X7-dependent large pore (LP) functions. Mechanisms governing this operational ...
P2RX7 purinoceptor as a therapeutic target – the second coming?
(2018-06-28)
The P2RX7 receptor is a unique member of a family of extracellular ATP (eATP)-gated
ion channels expressed in immune cells, where its activation triggers the inflammatory
cascade. Therefore, P2RX7 has been long investigated ...
O-3 Opioids, benzodiazepines, anti-cholinergic load and clinical outcomes in patients with advanced cancer
(BMJ Publishing, 2017-03-01)
Background Medications used to manage symptoms in patients with cancer have associated, but poorly understood, harms. The aim of this study was to explore the temporal relationship between oral morphine equivalent daily ...
Factors associated with stage at diagnosis in patients with head and neck cancer
(2017-02-23)
Studies have shown that diagnosis of head and neck cancer (HNC) at an advanced stage reduces the survival time compared to those diagnosed with limited disease but few have investigated the relationship of characteristics ...
