Show simple item record

dc.contributor.authorVaz, L R
dc.contributor.authorAveyard, P
dc.contributor.authorCooper, S
dc.contributor.authorLeonardi-Bee, J
dc.contributor.authorColeman, T
dc.contributor.authorWatts, K.
dc.date.accessioned2020-07-29T10:13:58Z
dc.date.available2020-07-29T10:13:58Z
dc.date.issued2016-10-01
dc.identifier.citationVaz, L.R., Aveyard, P., Cooper, S., Leonardi-Bee, J., Coleman, T., Watts, K. et al (2016) The association between treatment adherence to nicotine patches and smoking cessation in pregnancy: A secondary analysis of a randomized controlled trial. Nicotine and Tobacco Research, 18 (10), pp. 1952-1959en
dc.identifier.urihttps://dora.dmu.ac.uk/handle/2086/20027
dc.descriptionSecondary analysis of RCT open access articleen
dc.description.abstractIntroduction: In nonpregnant “quitters,” adherence to nicotine replacement therapy (NRT) increases smoking cessation. We investigated relationships between adherence to placebo or NRT patches and cessation in pregnancy, including an assessment of reverse causation and whether any adherence: cessation relationship is moderated when using nicotine or placebo patches. Methods: Using data from 1050 pregnant trial participants, regression models investigated associations between maternal characteristics, adherence and smoking cessation. Results: Adherence during the first month was associated with lower baseline cotinine concentrations (β −0.08, 95% confidence interval [CI] −0.15 to −0.01) and randomization to NRT (β 2.59, 95% CI 1.50 to 3.68). Adherence during both treatment months was associated with being randomized to NRT (β 0.51, 95% CI 0.29 to 0.72) and inversely associated with higher nicotine dependence. Adherence with either NRT or placebo was associated with cessation at 1 month (odds ratio [ OR ] 1.11, 95% CI 1.08 to 1.13) and delivery ( OR 1.06, 95% CI 1.03 to 1.09), but no such association was observed in the subgroup where reverse causation was not possible. Amongst all women, greater adherence to nicotine patches was associated with increased cessation ( OR 2.47, 95% CI 1.32 to 4.63) but greater adherence to placebo was not ( OR 0.98, 95% CI: 0.44 to 2.18). Conclusion: Women who were more adherent to NRT were more likely to achieve abstinence; more nicotine dependent women probably showed lower adherence to NRT because they relapsed to smoking more quickly. The interaction between nicotine-containing patches and adherence for cessation suggests that the association between adherence with nicotine patches and cessation may be partly causal.en
dc.language.isoenen
dc.publisherOxford Academicen
dc.titleThe association between treatment adherence to nicotine patches and smoking cessation in pregnancy: A secondary analysis of a randomized controlled trialen
dc.typeArticleen
dc.identifier.doihttps://doi.org/10.1093/ntr/ntw080
dc.peerreviewedYesen
dc.funderNIHR (National Institute for Health Research)en
dc.projectidHTA 06/07/01en
dc.cclicenceCC BYen
dc.date.acceptance2016-03-31
dc.researchinstituteInstitute of Health, Health Policy and Social Careen
dc.exception.ref2021codes254aen


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record