Browsing by Author "Jones, William"
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Mechanochemical Synthesis of Multicomponent Crystals: One Liquid for One Polymorph? A Myth to Dispel
Hasa, Dritan; Miniussi, Eugenia; Jones, William (Article)Identifying as many polymorphs as possible for a molecular compound is important in the design of materials with desired properties. In this paper we demonstrate, using a simple experimental procedure, how the amount of ... -
On the Kinetics of Solvate Formation through Mechanochemistry
Hasa, Dritan; Pastore, Mariana; Gabriele, Benjamin; Schneider Rauber, Gabriela; Bond, Andrew; Jones, William (Article)Theophylline:2-pyrrolidone mono (1:1) and sesqui (2:3) solvates have been discovered through variable-amount liquid-assisted grinding (VALAG). The structures and stability of the solvates and the kinetics involved in their ... -
Polymer-Assisted Grinding, a Versatile Method for Polymorph Control of Cocrystallization
Hasa, Dritan; Carlino, Elvio; Jones, William (Article)Despite the great interest that cocrystals are currently gaining for their application to the design of new supramolecular structures with desired functional properties, studies concerning new experimental strategies ... -
Screening for new pharmaceutical solid forms using mechanochemistry: A practical guide
Hasa, Dritan; Jones, William (Article)Within the pharmaceutical industry, and elsewhere, the screening for newsolid forms is a mandatory exercise for both existing and new chemical entities. This contribution focuses on mechanochemistry as a versatile approach ...